study Skeleton
since 1972 have been introduced phosphates and diphosphates Perla Studio 's bone imaging. Phosphate compounds (pyrophosphate, metilendifosfonato, idrossimetilendifosfonato), 99mTc-labeled radiopharmaceuticals are the most commonly used today to perform a scintigraphic study of the skeleton. The uptake of these radiopharmaceuticals by bone by bone occurs through mechanisms not yet fully understood. Through an initial chemo-absorbed on the surface of crystals of calcium idrossipatite newly formed. The deposition then essentially reflects the extent of osteoblastic phenomena, in fact, skeletal scintigraphy is a young person growing sites show net uptake in physiological bone growth. A skeletal maturation occurred in the scintigraphic images stand out on the basis of a diffuse and homogeneous uptake linked to the normal replacement mineral that constantly affects the whole skeleton, the mineral districts with the most intense parts. Thanks to rapid renal excretion, phosphates have a high ratio bone tissue / soft 2-3 hours after injection. 50-60% of the injected dose is localized to bone, and the remainder is excreted by the kidneys. The uptake of phosphate by bone is related to a high number of factors, contingency plans are important blood supply and the extent of bone tournover. Essential condition for the radiopharmaceutical to settle on a certain segment of bone is, in fact, that this bone segment receives an adequate blood supply. In fact, in cases of vascular necrosis, such as the femoral head, the scan here shows a lack of uptake in the early stages after the occurrence of disease (1-2 weeks). Only belatedly, started the phenomena of reparative bone remodeling, the edesima area previously "cold" shows uptake of rafiofarmaco. On the contrary phenomena are iperafflusso blood scintigraphically marked with an increased uptake of radiopharmaceutical.
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